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1. (WO2017092178) APPLICATION OF C-TYPE NATRIURETIC PEPTIDE IN THE PREPARATION OF TOPICAL CONTRACEPTIVE AND IN SPERM FUNCTION TEST
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/092178 International Application No.: PCT/CN2016/073667
Publication Date: 08.06.2017 International Filing Date: 05.02.2016
IPC:
A61K 38/17 (2006.01) ,A61K 38/22 (2006.01) ,C12Q 1/02 (2006.01) ,A61P 15/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
18
Feminine contraceptives
Applicants:
中国农业大学 CHINA AGRICULTURAL UNIVERSITY [CN/CN]; 中国北京市 海淀区圆明园西路2号 2 Yuanmingyuan Western Road, Haidian District Beijing 100193, CN
Inventors:
张美佳 ZHANG, Meijia; CN
夏国良 XIA, Guoliang; CN
孔娜娜 KONG, Nana; CN
张玉 ZHANG, Yu; CN
李佳 LI, Jia; CN
Agent:
北京路浩知识产权代理有限公司 CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED; 中国北京市 海淀区丹棱街3号中国电子大厦B座18层 18th Floor, Tower B, CEC Plaza No. 3 Dan Ling Street, Haidian District Beijing 100080, CN
Priority Data:
201510884049.204.12.2015CN
201610034944.X19.01.2016CN
Title (EN) APPLICATION OF C-TYPE NATRIURETIC PEPTIDE IN THE PREPARATION OF TOPICAL CONTRACEPTIVE AND IN SPERM FUNCTION TEST
(FR) APPLICATION DU PEPTIDE NATRIURÉTIQUE DE TYPE C DANS LA PRÉPARATION D'UN CONTRACEPTIF TOPIQUE ET DANS UN TEST FONCTIONNEL DU SPERME
(ZH) C-型钠肽在制备外用避孕药和精子功能检测中的应用
Abstract:
(EN) The present invention provides application of C-type natriuretic peptide in the preparation of a topical contraceptive and a sperm function test reagent. It is found in studies that at the time of ovulation, C-type natriuretic peptide is expressed at the ampulla of oviduct, at a site of fertilization, and this can induce the chemotactic movement of sperms toward an ovum to accomplish the fertilization. If a certain amount of C-type natriuretic peptide is added into the genital tract of a female mammal, or the C-type natriuretic peptide is incubated with the sperms, such that the concentration gradient distribution of the C-type natriuretic peptide in the oviduct is changed, the sperms cannot chemotactically move toward the ovum along the concentration gradient, and thus the fertilization is blocked.
(FR) La présente invention concerne l'application du peptide natriurétique de type C dans la préparation d'un contraceptif topique et d'un réactif pour un test fonctionnel du sperme. Il a été montré dans des études qu'au moment de l'ovulation le peptide natriurétique de type C est exprimé au niveau de l'ampoule tubaire de l'oviducte, au niveau d'un site de fertilisation, et que cela peut induire le mouvement chimiotactique des spermatozoïdes vers un ovule pour réaliser la fertilisation. Si une certaine quantité de peptide natriurétique de type C est ajouté dans le tractus génital d'un mammifère femelle, ou si le peptide natriurétique de type C est incubé avec les spermatozoïdes, de façon telle que la distribution du gradient de concentration du peptide natriurétique de type C dans l'oviducte est modifiée, les spermatozoïdes ne peuvent pas se déplacer par chimiotactisme vers l'ovule le long du gradient de concentration, et la fertilisation est de ce fait bloquée.
(ZH) 本发明提供了C-型钠肽在制备外用避孕药和精子功能检测试剂中的应用。研究发现,在排卵发生时,输卵管受精部位壶腹部表达C-型钠肽,能诱导精子向卵子趋化运动,完成受精。若在雌性哺乳动物生殖道内添加一定量的C-型钠肽,或将C-型钠肽与精子孵育,改变输卵管中C-型钠肽的浓度梯度分布,精子就不能顺着浓度梯度向卵子趋化运动,从而阻滞受精。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)