Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017091865) MONITORING TREATMENT OR PROGRESSION OF MYELOMA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/091865 International Application No.: PCT/AU2016/051191
Publication Date: 08.06.2017 International Filing Date: 02.12.2016
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
ALFRED HEALTH [AU/AU]; 55 Commercial Road Prahran, Victoria 3181, AU
Inventors:
SPENCER, Andrew; AU
MITHRAPRABHU, Sridurga; AU
Agent:
FPA PATENT ATTORNEYS PTY LTD; Level 43 101 Collins Street Melbourne, Victoria 3000, AU
Priority Data:
201590501303.12.2015AU
201690301901.08.2016AU
Title (EN) MONITORING TREATMENT OR PROGRESSION OF MYELOMA
(FR) SUIVI DU TRAITEMENT OU DE LA PROGRESSION D'UN MYÉLOME
Abstract:
(EN) The present invention relates to methods and kits for diagnosing myeloma, monitoring disease progression or treatment efficacy in an individual having a myeloma. In one aspect, the invention relates to A method for monitoring the response of an individual to treatment for multiple myeloma, the method comprising providing cell-free nucleic acids derived from a sample of peripheral blood from an individual that has undergone treatment for multiple myeloma; assessing the cell-free nucleic acids for a mutation in any one or more nucleotide sequences from a KRAS, NRAS, BRAF and/or TP53 gene; wherein an absence of, or reduction in the number of, mutations in a nucleotide sequence from a KRAS, NRAS, BRAF and/or TP53 gene indicates a response of the individual to treatment for multiple myeloma.
(FR) La présente invention concerne des procédés et des kits permettant de diagnostiquer un myélome, de surveiller la progression de la maladie ou l'efficacité d'un traitement chez un individu souffrant d'un myélome. Sous un aspect, l'invention concerne un procédé pour surveiller la réponse d'un individu à un traitement pour un myélome multiple, le procédé consistant à administrer des acides nucléiques acellulaires provenant d'un échantillon de sang périphérique d'un individu ayant subi un traitement pour un myélome multiple ; et évaluer les acides nucléiques acellulaires pour y chercher une mutation dans une ou plusieurs séquences nucléotidiques d'un gène KRAS, NRAS, BRAF et/ou TP53, une absence, ou une réduction du nombre de mutations dans une séquence nucléotidique d'un gène KRAS, NRAS, BRAF et/ou TP53 indiquant une réponse de l'individu au traitement pour un myélome multiple.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016363113CA3007426KR1020180088690US20180282820EP3384050CN108603232