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1. (WO2017090902) ORAL HEMOSTATIC AND WOUND-PROTECTIVE FILM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/090902 International Application No.: PCT/KR2016/012271
Publication Date: 01.06.2017 International Filing Date: 28.10.2016
IPC:
A61K 9/70 (2006.01) ,A61K 9/00 (2006.01) ,A61K 31/045 (2006.01) ,A61K 31/047 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
047
having two or more hydroxy groups, e.g. sorbitol
Applicants:
티비엠 주식회사 TBM COMPANY [KR/KR]; 광주시 북구 첨단과기로 313 B-301 B-301, 313 Cheomdangwagi-ro Buk-gu Gwangju 61008, KR
주식회사 착한생각 GOOD THINKING CO [KR/KR]; 광주시 광산구 여대길 201 201, Yeodae-gil Gwangsan-gu Gwangju 62396, KR
Inventors:
윤세영 YUN, Seiyeong; KR
Agent:
이준혁 LEE, Junhyek; KR
Priority Data:
10-2015-016539625.11.2015KR
10-2016-014169528.10.2016KR
Title (EN) ORAL HEMOSTATIC AND WOUND-PROTECTIVE FILM
(FR) FILM BUCCAL HÉMOSTATIQUE ET DE PROTECTION DES PLAIES
(KO) 구강 지혈 및 상처 보호 필름
Abstract:
(EN) The present invention relates to an oral hemostatic and wound-protective film which can be attached to a cut portion in an oral cavity so as to delay or prevent microbleeding and to control release of medicinal ingredients. The present invention comprises polyol, alcohol and a biodegradable polymer in a partly swollen state, thereby being capable of absorbing blood or abscesses in a topical region and stopping bleeding. Further, as the film of the present invention has a large elongation rate , it is possible to maintain an adhesive force after absorbing blood, saliva and abscesses in an oral cavity. In addition, as the film easily transforms to a topical site with curvatures, the film is less irritating even when attached to such a topical site for a long time. Further, as the film of the present invention comprises a disintegrating agent which is dissolved and released when reacting with blood to form microchannels serving as a drug release passage, it is possible to control a drug release amount by controlling the amount and size of the microchannels. Since an adhesive layer and a support layer of the present invention are dissolved and removed over time, a patient does not have to detach a transporter film attached in the oral cavity by hand .
(FR) La présente invention concerne un film buccal hémostatique et de protection des plaies qui peut être appliqué sur une zone coupée au niveau de la cavité buccale de façon à retarder ou empêcher des micro-saignements et pour contrôler la libération d'agents thérapeutiques. La présente invention comprend un polyol, un alcool et un polymère biodégradable sous un état partiellement gonflé, permettant de ce fait d'absorber le sang ou le pus au niveau de la zone d'application, et d'arrêter le saignement. En outre, le film selon l'invention présentant un taux d'allongement élevé, il est possible de maintenir une force d'adhésion après l'absorption de sang, de salive et de pus dans la cavité buccale. De plus, le film se déforme facilement au niveau des sites d'application présentant des courbures, le film est moins irritant même lorsqu'il est fixé à un tel site d'application pendant une durée prolongée. En outre, le film de la présente invention comprend un agent de désintégration qui est dissout et libéré lorsqu'il réagit avec le sang, conduisant à la formation de microcanaux servant de voie de libération pour des médicaments, il est possible de contrôler la quantité de médicament libérée en contrôlant le nombre et la taille des microcanaux. La couche adhésive et la couche de support de la présente invention étant dissoutes et éliminées au cours du temps, un patient n'a pas à détacher manuellement de film de transport fixé dans la cavité buccale.
(KO) 본 발명은 구강의 창상부위에 부착되어 미세출혈을 지연 또는 방지하고, 약효성분 방출을 제어할 수 있는 구강 지혈 및 상처 보호 필름에 관련된다. 본 발명은 폴리올, 알코올 및 biodegradable polymer를 부분 팽윤 상태로 포함하여 국소부위의 혈액이나 농양을 흡수 및 지혈할 수 있다. 또한, 본 발명의 필름은 신장율이 커서 구강내의 혈액, 타액 및 농양을 흡수하여도 부착력을 유지할 수 있고, 굴곡이 많은 국소부위에 따라 형태의 변형이 용이하여서 국소부위에 장시간 부착하여도 이물감이 낮다. 또한, 본 발명의 필름은 혈액과 반응시 용해 방출되어 약물 방출 통로가 되는 미세채널을 형성하는 붕해제를 포함하여 상기 채널의 양과 크기를 조절하여 약물 방출량을 제어할 수 있다. 본 발명은 점착층과 지지체층이 시간 경과에 따라 모두 소실되어 제거되므로 환자가 손으로 구강내 부착된 전달체 필름을 탈착할 필요가 없다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)
Also published as:
CN107106512US20170296157IN201737029805ID2018/04400EP3381448JP2018538233
CA3044944