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1. WO2017087831 - COMPETITIVE LATERAL FLOW ASSAY

Publication Number WO/2017/087831
Publication Date 26.05.2017
International Application No. PCT/US2016/062828
International Filing Date 18.11.2016
IPC
G01N 21/55 2014.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
55Specular reflectivity
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
G01N 33/558
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
558using diffusion or migration of antigen or antibody
G01N 33/82
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
82involving vitamins ; or their receptors
Applicants
  • CORNELL UNIVERSITY [US]/[US]
Inventors
  • ERICKSON, David
  • LEE, Seoho
  • MEHTA, Saurabh
  • VEMULAPATI, Sasank, Sai
  • REY, Elizabeth, Grace
  • O'DELL, Dakota
Agents
  • GOLDMAN, Michael, L.
  • MERKEL, Edwin, V.
  • TISCHNER, Tate, L.
  • SMITH, Bryan, C.
  • LEINBERG, Gunnar, G.
Priority Data
62/256,94618.11.2015US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPETITIVE LATERAL FLOW ASSAY
(FR) ANALYSE À FLUX LATÉRAL COMPÉTITIF
Abstract
(EN) The present invention relates to a competitive diagnostic assay strip for detection of a target molecule in a sample. The strip includes an elongated substrate extending between a first end at which the sample is applied to the strip and a second end at which results of the assay can be assessed. A first layer is supported on the substrate for receiving, absorbing, and filtering a liquid sample. A second layer is supported on the substrate, wherein the second layer comprising a mobile labelled specific binding partner of a target molecule. A third layer is supported on the substrate, the third layer comprising a test region and a control region separated from the test region. The test region has immobilized target molecules. Yet another aspect of the present invention relates to a method of conducting a diagnostic assay. The method includes providing a competitive diagnostic assay strip in accordance with the present invention.
(FR) La présente invention concerne une bande d'analyse de diagnostic compétitif pour la détection d'une molécule cible dans un échantillon. La bande comprend un substrat allongé s'étendant entre une première extrémité à laquelle l'échantillon est appliqué sur la bande et une seconde extrémité à laquelle des résultats d'analyse peuvent être évalués. Une première couche est placée sur le substrat pour recevoir, absorber et filtrer un échantillon liquide. Une deuxième couche est placée sur le substrat, la deuxième couche comprenant un partenaire de liaison spécifique marqué mobile d'une molécule cible. Une troisième couche est placée sur le substrat, la troisième couche comprenant une région d'analyse et une région de témoin séparée de la région d'analyse. La région d'analyse comprend des molécules cibles immobilisées. Un autre aspect de la présente invention concerne un procédé de réalisation d'une analyse de diagnostic. Le procédé consiste à fournir une bande d'analyse de diagnostic compétitif selon la présente invention.
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