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1. (WO2017070654) PROGRAMMABLE UNIVERSAL CELL RECEPTORS AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/070654 International Application No.: PCT/US2016/058429
Publication Date: 27.04.2017 International Filing Date: 24.10.2016
IPC:
A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,C07K 16/46 (2006.01) ,C07K 16/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants: SORRENTO THERAPEUTICS, INC.[US/US]; 9380 Judicial Drive San Diego, CA 92121, US
Inventors: KAUFMANN, Gunnar, Jörg Floris; US
FU, Yanwen; US
ZHANG, Yan-liang; US
PATTERSON, James, T.; US
Agent: HERRITT, Danielle, L.; US
ACETO, Donato; US
BARBIC, Andrej; US
BAI, Mei; US
BELT, Erik, P.; US
Priority Data:
62/245,97823.10.2015US
62/382,69101.09.2016US
Title (EN) PROGRAMMABLE UNIVERSAL CELL RECEPTORS AND METHODS OF USING THE SAME
(FR) RÉCEPTEURS DE CELLULES UNIVERSELS PROGRAMMABLES ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present invention provides programmable universal cell receptors (PUCRs) comprising a catalytic antibody region, a transmembrane domain and a cytoplasmic domain. The PUCRs disclosed herein may be conjugated to a specificity agent in order to program the receptor for specificity to any molecule of interest. Also provided are nucleic acids encoding such PUCRs, and cells expressing the PUCRs. Such cells may be used in treating a variety of medical conditions and diseases including cancer and infectious diseases.
(FR) La présente invention concerne des récepteurs de cellules universels programmables (PUCR) comprenant une région d'anticorps catalytique, un domaine transmembranaire et un domaine cytoplasmique. Les PUCR selon l'invention peuvent être conjugués à un agent de spécificité afin de programmer le récepteur pour une spécificité concernant n'importe quelle molécule d'intérêt. L'invention concerne également des acides nucléiques codant de tels PUCR et des cellules exprimant les PUCR. De telles cellules peuvent être utilisées dans le traitement d'une pluralité d'états médicaux et de maladies comprenant le cancer et des maladies infectieuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)