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1. (WO2017070608) ANTIBODY/T-CELL RECEPTOR CHIMERIC CONSTRUCTS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/070608    International Application No.:    PCT/US2016/058305
Publication Date: 27.04.2017 International Filing Date: 21.10.2016
IPC:
C07K 14/725 (2006.01), A61K 38/17 (2006.01), A61K 35/17 (2015.01), C12N 15/62 (2006.01), C12N 15/63 (2006.01)
Applicants: EUREKA THERAPEUTICS, INC. [US/US]; 5858 Horton Street, Suite 370 Emeryville, CA 94608 (US)
Inventors: LU, Jingwei; (US).
YANG, Zhiyuan; (US).
LIU, Cheng; (US).
LIU, Hong; (US).
XU, Yiyang; (US).
YAN, Su; (US).
CHAN, Vivien Wai-fan; (US).
HORAN, Lucas; (US)
Agent: VANEVSKI, Filip; (US).
BASOL, Erol, C.; (US).
BANKO, Max; (US).
AHN, Sejin; (US).
ARJOMAND, Mehran; (US)
Priority Data:
62/345,649 03.06.2016 US
62/304,918 07.03.2016 US
62/369,694 01.08.2016 US
62/245,944 23.10.2015 US
Title (EN) ANTIBODY/T-CELL RECEPTOR CHIMERIC CONSTRUCTS AND USES THEREOF
(FR) CONSTRUCTIONS CHIMÉRIQUES D'ANTICORPS/RÉCEPTEURS DES LYMPHOCYTES T ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
(FR)La présente invention concerne des constructions chimériques d'anticorps-TCR comprenant une fraction d'anticorps qui se lie spécifiquement à un antigène cible fusionné à un TCRM pouvant recruter au moins un module de signalisation lié au TCR. L'invention concerne en outre des procédés de production et d'utilisation desdites constructions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)