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1. (WO2017070606) COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/070606 International Application No.: PCT/US2016/058303
Publication Date: 27.04.2017 International Filing Date: 21.10.2016
IPC:
A61K 39/395 (2006.01) ,A61K 31/135 (2006.01) ,A61K 31/53 (2006.01) ,A61K 35/17 (2015.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
[IPC code unknown for A61K 35/17]
Applicants: TECLISON LIMITED; Oleander Way, 802 West Bay Road P. O. Box 32052 Grand Cayman, KY1-1208, KY
Inventors: LEE, Ruey-min; US
Agent: STRONCEK, Jacqueline; US
ADVANI, Raj; US
AGRAWAL, Trisha; US
ALEMOZAFAR, Ali; US
STRONCEK, Jacqueline; US
Priority Data:
62/244,45721.10.2015US
Title (EN) COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY
(FR) COMPOSITIONS ET PROCÉDÉS POUR THÉRAPIE ANTICANCÉREUSE À MÉDIATION IMMUNITAIRE
Abstract:
(EN) Disclosed herein are methods and compositions for enhancing an immune response to a solid tumor in a subject. In some embodiments, a method comprises: (a) administering to the subject a hypoxia-activated bioreductive agent (HABA); (b) inducing hypoxia by (i) administering a hypoxia-inducing agent to the subject or (ii) embolizing one or more blood vessels supplying the solid tumor; and (c) administering an immune checkpoint inhibitor prior to, simultaneously with, or subsequent to step (b) in an amount effective to enhance an immune response to the solid tumor, as compared to an immune response in the absence of the immune checkpoint inhibitor. Kits for use in the disclosed methods are also provided.
(FR) La présente invention concerne des procédés et des compositions pour augmenter une réponse immunitaire à une tumeur solide chez un sujet. Dans certains modes de réalisation, un procédé comprend : (a) l’administration au sujet d’un agent bioréducteur activé par l’hypoxie (HABA) ; (b) l’induction de l’hypoxie par (i) administration d’un agent inducteur d’hypoxie au sujet (ii) embolisation d’un ou plusieurs vaisseaux sanguins alimentant la tumeur solide ; et (c) l’administration d’un inhibiteur de point de contrôle immunitaire avant, simultanément avec, ou après l’étape (b) en une quantité efficace pour augmenter une réponse immunitaire à la tumeur solide, par rapport à une réponse immunitaire en l’absence de l’inhibiteur de point de contrôle immunitaire. L’invention concerne en outre des trousses pour utilisation dans les procédés de l’invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)