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1. (WO2017070578) DETECTION AND TREATMENT OF CARIES AND MICROCAVITIES WITH NANOPARTICLES

Pub. No.:    WO/2017/070578    International Application No.:    PCT/US2016/058274
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 22 01:59:59 CEST 2016
IPC: A61K 49/18
A61K 49/00
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
POZNAN UNIVERSITY OF MEDICAL SCIENCES
Inventors: LAHANN, Joerg
CHANG, Sywe-Ren
CLARKSON, Brian
JONES, Nathan A.
CZAJKA-JAKUBOWSKA, Agata
Title: DETECTION AND TREATMENT OF CARIES AND MICROCAVITIES WITH NANOPARTICLES
Abstract:
Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer {e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent {e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.