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1. (WO2017070568) IMPROVED SYNTHESIS OF HONOKIOL

Pub. No.:    WO/2017/070568    International Application No.:    PCT/US2016/058258
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 22 01:59:59 CEST 2016
IPC: A61K 31/05
C07C 39/21
Applicants: COLGATE-PALMOLIVE COMPANY
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors: JARACZ, Stanislav
KOZLOWSKI, Marisa
EUN LEE, Young
KIM, Sun Min
Title: IMPROVED SYNTHESIS OF HONOKIOL
Abstract:
Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3'-di-tert-butyl-5,5'-dimethyl-[1,1'-biphenyl]-2,4'-diol, 3',5-dimethyl-[1,1'-biphenyl]-2,4'-diol, and 2,4'-dimethoxy-3',5-dimethyl-1,1'-biphenyl, 3,3',5,5'-tetra-tert-butyl-[1,1'-biphenyl]-2,4'-diol, and certain tetrasubstituted bisphenols, and uses therefor.