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1. (WO2017070566) ENHANCED ABUSE-DETERRENT FORMULATIONS OF OXYCODONE

Pub. No.:    WO/2017/070566    International Application No.:    PCT/US2016/058256
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 22 01:59:59 CEST 2016
IPC: A61K 9/20
Applicants: KASHIV PHARMA LLC
Inventors: BANERJEE, Siddhartha
SHAH, Navnit, H.
PATEL, Gaurang
BOMMANA, Murali, Mohan
CHATTERJI, Ashish
KUMAR, Anita
INBAR, Petra
LIU, Furong
KONE, Srinivas
JAGANI, Priti, L.
PHUAPRADIT, Wantanee
Title: ENHANCED ABUSE-DETERRENT FORMULATIONS OF OXYCODONE
Abstract:
The present technology relates to an extended-release solid oral pharmaceutical composition, comprising a cured blend of a melt-extruded first component and a second component, wherein the melt-extruded first component comprises a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof, at least one PEO polymer, and a stabilizing agent; and the second component comprises at least one PEO polymer and an oxidative stabilizing agent. The extended-release pharmaceutical compositions of the present technology provide crush-resistant and abuse-deterrent formulations featuring enhanced heat stability, resistance to drug segregation, and resistance to alcohol-induced dose dumping.