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|1. (WO2017070566) ENHANCED ABUSE-DETERRENT FORMULATIONS OF OXYCODONE|
|Applicants:||KASHIV PHARMA LLC
SHAH, Navnit, H.
BOMMANA, Murali, Mohan
JAGANI, Priti, L.
|Title:||ENHANCED ABUSE-DETERRENT FORMULATIONS OF OXYCODONE|
The present technology relates to an extended-release solid oral pharmaceutical composition, comprising a cured blend of a melt-extruded first component and a second component, wherein the melt-extruded first component comprises a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof, at least one PEO polymer, and a stabilizing agent; and the second component comprises at least one PEO polymer and an oxidative stabilizing agent. The extended-release pharmaceutical compositions of the present technology provide crush-resistant and abuse-deterrent formulations featuring enhanced heat stability, resistance to drug segregation, and resistance to alcohol-induced dose dumping.