WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2017070565) HETEROCYCLIC PDK1 INHIBITORS FOR USE TO TREAT CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/070565    International Application No.:    PCT/US2016/058255
Publication Date: 27.04.2017 International Filing Date: 21.10.2016
IPC:
A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61K 31/506 (2006.01), A61K 31/517 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: SUNESIS PHARMACEUTICALS, INC. [US/US]; 395 Oyster Point Blvd., Suite 400 South San Francisco, California 94080 (US)
Inventors: HANSEN, Stig K.; (US).
BINNERTS, Minke E.; (US)
Agent: ERLACHER, Heidi; (US).
BUTEAU, Kristen C.; (US).
CAHILL, John J.; (US).
HAULBROOK, William R.; (US).
JARRELL, Brenda Herschbach; (US).
LI, Xiaodong; (US).
LYON, Charles E.; (US).
MEDINA, Rolando; (US).
MONROE, Margo R.; (US).
NGUYEN, Suzanne P.; (US).
NIHAN, Danielle M.; (US).
PACE, Nicholas J.; (US).
PELLIGRINO, Jeffrey S.; (US).
PYSHER, Paul A.; (US).
REESE, Brian E.; (US).
ROHLFS, Elizabeth M.; (US).
SAHR, Robert N.; (US).
SHAIKH, Nishat A.; (US).
SHINALL, Michael A.; (US).
SMITH, Maria C.; (US).
SUH, Su Kyung; (US).
VRABLIK, Tracy L.; (US)
Priority Data:
62/245,606 23.10.2015 US
Title (EN) HETEROCYCLIC PDK1 INHIBITORS FOR USE TO TREAT CANCER
(FR) INHIBITEURS DE PDK1 HÉTÉROCYCLIQUES DESTINÉS À ÊTRE UTILISÉS POUR TRAITER LE CANCER
Abstract: front page image
(EN)Described are methods of use of compounds that inhibit PIF-mediated substrate binding by PDK1, which are useful as inhibitors of cancer growth or proliferation that is RSK2-dependent or AKT-independent. Also described are compositions of such compounds for use in such methods of treating cancer.
(FR)L'invention concerne des méthodes d'utilisation de composés qui inhibent la liaison au substrat par PDK1 à médiation par PIF, utiles en tant qu'inhibiteurs de la croissance du cancer ou de sa prolifération qui est dépendante de la kinase RSK2 ou indépendante de la kinase AKT. L'invention concerne également des compositions de tels composés pour une utilisation dans de tels méthodes de traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)