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1. (WO2017070561) ANTI-IL-2 ANTIBODIES AND COMPOSITIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/070561 International Application No.: PCT/US2016/058249
Publication Date: 27.04.2017 International Filing Date: 21.10.2016
IPC:
C07K 16/24 (2006.01) ,A61K 39/00 (2006.01)
Applicants: PFIZER INC.[US/US]; 235 East 42nd Street New York, NY 10017, US
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA[US/US]; 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200, US
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY[US/US]; Building 170, 3rd Floor, Main Quad Stanford, CA 94305, US
Inventors: RONDON, Isaac J.; US
CRELLIN, Natasha; US
BESSETTE, Paul; US
TROTTA, Eleonora; US
BLUESTONE, Jeffrey A.; US
ELY, Lauren K.; US
GARCIA, Kenan Christopher; US
Agent: FLANAGAN, Lisa Dornbach; US
MURPHEY, Ryan, D.; US
Priority Data:
62/245,60023.10.2015US
62/408,36014.10.2016US
Title (EN) ANTI-IL-2 ANTIBODIES AND COMPOSITIONS AND USES THEREOF
(FR) ANTICORPS ANTI-IL-2, COMPOSITIONS LES CONTENANT ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Ra and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
(FR) La présente invention concerne des anticorps, ou des parties de liaison à l'antigène de ceux-ci, qui se lient spécifiquement à IL-2 et réduisent l'affinité de la liaison à IL -2 IL-2Ra et IL-2 Rβ. L'invention concerne en outre un procédé d'obtention de ces anticorps et des acides nucléiques codant pour eux. L'invention concerne également des compositions et des méthodes thérapeutiques pour l'utilisation de ces anticorps pour le traitement et/ou la prévention de maladies, troubles ou affections auto-immuns et pour l'immunosuppression, comprenant, mais sans s'y limiter, l'administration d'un complexe comprenant l'anticorps et l'IL-2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)