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1. (WO2017070554) METHODS TO CREATE CHEMICALLY-INDUCED DIMERIZING PROTEIN SYSTEMS FOR REGULATION OF CELLULAR EVENTS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/070554 International Application No.: PCT/US2016/058237
Publication Date: 27.04.2017 International Filing Date: 21.10.2016
IPC:
C12N 9/96 (2006.01) ,C12N 5/0783 (2010.01) ,C12N 9/50 (2006.01)
Applicants: FRED HUTCHINSON CANCER RESEARCH CENTER[US/US]; 1100 Fairview Avenue North J2-302 Seattle, Washington 98109, US
Inventors: AMIN, Rupesh; US
Agent: WINGER, C. Rachal; US
Priority Data:
62/245,75623.10.2015US
Title (EN) METHODS TO CREATE CHEMICALLY-INDUCED DIMERIZING PROTEIN SYSTEMS FOR REGULATION OF CELLULAR EVENTS
(FR) MÉTHODES POUR CRÉER DES SYSTÈMES DE PROTÉINES DE DIMÉRISATION INDUITE CHIMIQUEMENT POUR LA RÉGULATION D'ÉVÉNEMENTS CELLULAIRES
Abstract: front page image
(EN) Methods to create chemically-induced dimerizing (CID) protein systems and uses thereof are described. The methods utilize antibody binding domain dimerizing proteins. The created systems can be used to regulate cellular events such as gene expression, receptor signaling and cell death to effectuate a variety of clinically relevant treatment outcomes.
(FR) L'invention concerne des méthodes pour créer des systèmes de protéines de dimérisation induite chimiquement (CID) et leurs utilisations. Les méthodes utilisent des protéines de dimérisation du domaine de liaison d'anticorps. Les systèmes créés peuvent être utilisés pour réguler les événements cellulaires tels que l'expression génique, la signalisation de récepteurs et la mort cellulaire afin d'obtenir une diversité de résultats de traitement cliniquement pertinents.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)