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1. (WO2017070538) INHIBITION OF MULTIPLE PATHOGENIC AGENTS USING BITHIONOL

Pub. No.:    WO/2017/070538    International Application No.:    PCT/US2016/058216
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 22 01:59:59 CEST 2016
IPC: A61K 31/095
A61K 31/03
A61K 31/055
A61K 39/07
C12R 1/16
Applicants: KECK GRADUATE INSTITUTE OF APPLIED LIFE SCIENCES
Inventors: MARTCHENKO, Mikhail
LEONARDI, William
Title: INHIBITION OF MULTIPLE PATHOGENIC AGENTS USING BITHIONOL
Abstract:
Compositions and methods including Bithionol are provided for treating, inhibiting, or preventing caspase-dependent pathogenic agents in a host cell or infected subject. Examples of caspase-dependent pathogenic agents include ricin, anthrax toxin, Botulinum neurotoxin A, diphtheria toxin, Pseudomonas aeruginosa exotoxin A, cholera toxin, Zika virus, and combinations thereof. Compositions and methods also include Bithionol in combination with an antibiotic for more effective clearance of the pathogen and/or toxins.