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1. (WO2017070506) DERIVATION OF HUMAN SKIN ORGANOIDS FROM PLURIPOTENT STEM CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/070506    International Application No.:    PCT/US2016/058174
Publication Date: 27.04.2017 International Filing Date: 21.10.2016
IPC:
A61L 27/38 (2006.01), A61L 27/60 (2006.01), A61K 35/36 (2015.01), C12N 5/071 (2010.01), C12N 5/074 (2010.01)
Applicants: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US/US]; 351 W. 10th Street, Suite 210 Indianapolis, IN 46202 (US)
Inventors: KOEHLER, Karl, R.; (US).
LEE, Jiyoon; (US)
Agent: LEWIS, Jessica, L.; (US)
Priority Data:
62/244,612 21.10.2015 US
Title (EN) DERIVATION OF HUMAN SKIN ORGANOIDS FROM PLURIPOTENT STEM CELLS
(FR) DÉRIVATION D'ORGANOÏDES CUTANÉS HUMAINS À PARTIR DE CELLULES SOUCHES PLURIPOTENTES
Abstract: front page image
(EN)Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.
(FR)La présente invention concerne des procédés permettant d’orienter la différenciation de cellules souches pluripotentes humaines en une composition de peau multicouche en trois dimensions comprenant une couche épidermique, une couche dermique, et une pluralité de cellules apte à former un follicule pileux fonctionnel. L'invention concerne également des compositions de peau manipulées multicouche en trois dimensions et leurs procédés d’utilisation destinée au criblage de médicaments, au criblage de composés agissant sur la pousse des cheveux, et à d'autres applications.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)