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1. (WO2017070471) METHODS OF GENERATING HUMAN INNER EAR SENSORY EPITHELIA AND SENSORY NEURONS

Pub. No.:    WO/2017/070471    International Application No.:    PCT/US2016/058121
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 22 01:59:59 CEST 2016
IPC: C12N 5/02
C12N 5/0793
C12N 5/0797
C12N 5/22
Applicants: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Inventors: KOEHLER, Karl, R.
HASHINO, Eri
Title: METHODS OF GENERATING HUMAN INNER EAR SENSORY EPITHELIA AND SENSORY NEURONS
Abstract:
Provided herein are methods for directing differentiation of human pluripotent stem cells into inner ear sensory epithelia and sensory neurons. More particularly, provided herein are methods for obtaining three-dimensional cultures comprising human pluripotent stem cell- derived pre-otic epithelium, otic vesicles, and inner ear sensory epithelia containing hair cells, sensory neurons, and supporting cells.