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1. (WO2017070456) METHODS OF TREATING CANCER BY ADMINISTERING A BISPECIFIC ANTIBODY ANTAGONIST OF IGF-IR AND ERBB3 AND A COMBINATION OF ANTI-EGFR ANTIBODIES

Pub. No.:    WO/2017/070456    International Application No.:    PCT/US2016/058089
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 22 01:59:59 CEST 2016
IPC: C07K 14/435
C07K 16/32
Applicants: MERRIMACK PHARMACEUTICALS, INC.
Inventors: BAZDAR-VINOVRSKI, Biljana
LAHDENRANTA, Maria, Johanna
MACBEATH, Gavin
MOYO, Victor
WAINSZELBAUM, Marisa
Title: METHODS OF TREATING CANCER BY ADMINISTERING A BISPECIFIC ANTIBODY ANTAGONIST OF IGF-IR AND ERBB3 AND A COMBINATION OF ANTI-EGFR ANTIBODIES
Abstract:
Provided are methods for clinical treatment of cancers (e.g., an Insulin Growth Factor 1 (IGF-1) positive cancer) using a bispecific antibody antagonist of IGF-IR and ErbB3 (e.g., istiratumab) in combination with anti-EGFR antibodies (e.g., MM-151). In one embodiment, the cancer is non- small-cell lung cancer (NSCLC), squamous cell carcinoma of the head and neck (SCCHN), or colorectal cancer (CRC).