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1. (WO2017070328) STIMULATION OF 11β-HSD2 EXPRESSION TO IMPROVE HORMONAL THERAPY OF STEROID-DEPENDENT DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/070328    International Application No.:    PCT/US2016/057884
Publication Date: 27.04.2017 International Filing Date: 20.10.2016
IPC:
A61K 45/06 (2006.01), A61K 31/407 (2006.01), A61K 31/4166 (2006.01), A61K 31/5375 (2006.01), A61K 31/69 (2006.01), A61P 35/04 (2006.01)
Applicants: THE CLEVELAND CLINIC FOUNDATION [US/US]; 9500 Euclid Avenue Cleveland, Ohio 44195 (US)
Inventors: SHARIFI, Nima; (US)
Agent: WESORICK, Richard S.; (US)
Priority Data:
62/243,827 20.10.2015 US
Title (EN) STIMULATION OF 11β-HSD2 EXPRESSION TO IMPROVE HORMONAL THERAPY OF STEROID-DEPENDENT DISEASE
(FR) STIMULATION DE L'EXPRESSION DE 11Β-HSD2 POUR AMÉLIORER UNE HORMONOTHÉRAPIE D'UNE MALADIE DÉPENDANTE DES STÉROÏDES
Abstract: front page image
(EN)A method of treating a steroid-dependent disease in a subject is described. The method includes providing steroid hormonal therapy to the subject while inhibiting glucocorticoid receptor activity, or by stimulating the expression of 11 β -HSD2.
(FR)La présente invention concerne une méthode de traitement d'une maladie dépendante des stéroïdes chez un sujet. Ladite méthode comprend les étapes consistant à administrer au sujet une hormonothérapie à base de stéroïdes, tout en inhibant l'activité du récepteur des glucocorticoïdes ou en stimulant l'expression de 11 β -HSD2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)