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1. (WO2017070224) MICROFLUIDIC MODEL OF THE BLOOD BRAIN BARRIER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/070224 International Application No.: PCT/US2016/057724
Publication Date: 27.04.2017 International Filing Date: 19.10.2016
IPC:
C12M 1/34 (2006.01) ,C12M 3/00 (2006.01) ,C12N 5/0793 (2010.01) ,C12N 5/0797 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
34
Measuring or testing with condition measuring or sensing means, e.g. colony counters
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
079
Neural cells
0793
Neurons
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
079
Neural cells
0797
Stem cells; Progenitor cells
Applicants: EMULATE, INC.[US/US]; 27 Drydock Boston, MA 02110, US
CEDARS-SINAI MEDICAL CENTER[US/US]; 8700 Beverly Blvd. Los Angeles, CA 90048, US
Inventors: KERNS, S., Jordan; US
WEN, Norman; US
LUCCHESI, Carol; US
HINOJOSA, Chris; US
FRASER, Jacob; US
HAMILTON, Geraldine; US
VATINE, Gad; US
SANCES, Samuel; US
SVENDSEN, Clive; US
LEVNER, Daniel; US
SAREEN, Dhruv; US
Agent: CARROLL, Peter, G.; US
HOWERTON, Thomas, C.; US
HAMDAN, Maha, A.; US
KELLY, Gilbert, Thomson; US
Priority Data:
62/243,64219.10.2015US
62/277,72312.01.2016US
62/332,72706.05.2016US
62/380,78029.08.2016US
Title (EN) MICROFLUIDIC MODEL OF THE BLOOD BRAIN BARRIER
(FR) MODÈLE MICROFLUIDIQUE DE LA BARRIÈRE HÉMATO-ENCÉPHALIQUE
Abstract:
(EN) The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
(FR) L'invention concerne la culture de cellules endothéliales cérébrales, et éventuellement d'astrocytes et de neurones dans un dispositif fluidique dans des conditions dans lesquelles les cellules imitent la structure et la fonction de la barrière hémato-encéphalique. La culture de telles cellules dans un dispositif microfluidique, soit seules soit en combinaison avec d'autres cellules, entraîne une maturation et/ou une différenciation plus poussée que dans les systèmes existants.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)