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1. (WO2017069829) HIGH-THROUGHPUT STRATEGY FOR DISSECTING MAMMALIAN GENETIC INTERACTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/069829    International Application No.:    PCT/US2016/044969
Publication Date: 27.04.2017 International Filing Date: 01.08.2016
IPC:
C12N 15/10 (2006.01), C12N 15/63 (2006.01), C12N 15/85 (2006.01), C12Q 1/68 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; West 116th Street And Broadway New York, NY 10027 (US)
Inventors: WANG, Harris; (US).
SHAPIRA, Sagi; (US).
STOCKMAN, Victoria; (US)
Agent: DAVITZ, Michael A.; (US).
LEASON, David; (US).
ELLIS, Edward, J.; (US).
CHENG, Susie; (US).
KRAMER CARNEY, Bonnie; (US)
Priority Data:
62/199,291 31.07.2015 US
Title (EN) HIGH-THROUGHPUT STRATEGY FOR DISSECTING MAMMALIAN GENETIC INTERACTIONS
(FR) STRATÉGIE HAUT DÉBIT POUR DISSÉQUER DES INTERACTIONS GÉNÉTIQUES DE MAMMIFÈRES
Abstract: front page image
(EN)The present disclosure provides for a rapid and systematic method to map genetic interactions using the CRISPR/Cas system. A set of genes, such as the entire genome of an organism, can he targeted in pairs by a CRISPR guide RNA library. Each vector of the library contains at least two CRISPR guide sequences which encode gRNAs, The library can target all genes of the set in a pairwise fashion.
(FR)La présente invention concerne un procédé rapide et systématique permettant de cartographier les interactions génétiques en utilisant le système CRISPR/Cas. Un ensemble de gènes, comme tout le génome d'un organisme, peut être ciblé en paires par une banque d'ARN de guide CRISPR. Chaque vecteur de la banque contient au moins deux séquences guides CRISPR qui codent pour les ARNg. La banque peut cibler tous les gènes de l'ensemble en paires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)