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1. (WO2017069612) METHOD FOR IMPROVING WHITE MATTER INTEGRITY IN HYPERPHENYLALANINEMIA AND PHENYLKETONURIA PATIENTS

Pub. No.:    WO/2017/069612    International Application No.:    PCT/NL2015/050739
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 24 01:59:59 CEST 2015
IPC: A61K 38/01
A61K 31/198
A61K 31/20
A61K 31/7068
A61K 31/7072
Applicants: N.V. NUTRICIA
Inventors: SAVELKOUL, Paul Johannes Maria
VERKUYL, Jan Martin
HAGEMAN, Robert Johan Joseph
DE WILDE, Mattheus Cornelis
COUNOTTE, Danielle Stefanie
RAKHSHANDEHROO, Maryam
Title: METHOD FOR IMPROVING WHITE MATTER INTEGRITY IN HYPERPHENYLALANINEMIA AND PHENYLKETONURIA PATIENTS
Abstract:
The invention pertains to the use of a composition in the manufacture of a productor method for therapeutically improving, promoting, restoring or maintaining white matter integrity in a subject suffering from PKU and/or in a subject suffering from or at increased risk of impaired white matter integrity associated with PKU, said composition comprising therapeutic amounts of at least one ω-3 polyunsaturated fatty acid (LCPUFA) selected from the group consisting of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA); and one of more of uridine, cytidine and/or an equivalent thereof, including salts, phosphates, acyl derivatives and/or esters. The invention also pertains to a composition for use in such use or method.