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1. (WO2017068190) RECOMBINANT MOPEIA VIRUS AND VACCINE PLATFORM
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/068190 International Application No.: PCT/EP2016/075573
Publication Date: 27.04.2017 International Filing Date: 24.10.2016
IPC:
A61K 39/12 (2006.01) ,C12N 9/22 (2006.01)
Applicants: INSTITUT PASTEUR[FR/FR]; 25-28, rue du Docteur Roux 75015 Paris, FR
Inventors: BAIZE, Sylvain; FR
PAGE, Audrey; FR
CARNEC, Xavier; FR
MATEO, Mathieu, Jean, Simon; FR
REYNARD, Stéphanie; FR
FIZET, Alexandra; FR
Agent: REGIMBEAU; 20, rue de Chazelles 75847 Paris Cedex 17, FR
Priority Data:
62/245,63123.10.2015US
Title (EN) RECOMBINANT MOPEIA VIRUS AND VACCINE PLATFORM
(FR) VIRUS RECOMBINÉ DE MOPEIAET PLATE-FORME VACCINALE
Abstract:
(EN) A recombinant attenuated Mopeia virus (MOPV) comprising a recombinant genomic S segment that encodes a nucleoprotein having attenuated exonuclease activity, and optionally further encodes a non-MOPV arenavirus glycoprotein. Use of the recombinant attenuated MOPV to induce an immune response in a subject.
(FR) L'invention concerne un virus atténué recombiné de Mopeia (MOPV) comprenant un segment S génomique recombiné qui code pour une nucléoprotéine ayant une activité exonucléase atténuée, et codant éventuellement encore pour une glycoprotéine arénavirus non-MOPV. L'invention concerne enfin l'utilisation de MOPV atténué recombiné pour induire une réponse immunitaire chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)