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Machine translation
1. (WO2017067592) CYTOTOXIC IMMUNOSTIMULATING PARTICLES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/067592    International Application No.:    PCT/EP2015/074386
Publication Date: 27.04.2017 International Filing Date: 21.10.2015
IPC:
A61K 39/39 (2006.01)
Applicants: BIONTECH AG [DE/DE]; An der Goldgrube 12 55131 Mainz (DE)
Inventors: PASCOLO, Steve; (CH)
Agent: SCHNAPPAUF, Georg; (DE)
Priority Data:
Title (EN) CYTOTOXIC IMMUNOSTIMULATING PARTICLES AND USES THEREOF
(FR) PARTICULES IMMUNOSTIMULANTES CYTOTOXIQUES ET UTILISATION DE CES DERNIÈRES
Abstract: front page image
(EN)The present invention relates to particles comprising RNA, in which the RNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid, wherein the RNA comprises a cytotoxic nucleotide or cytotoxic nucleotide analog and/or the RNA is covalently attached to a cytotoxin, pharmaceutical compositions containing said particles and pharmaceutical uses of the particles and pharmaceutical compositions. The particles of the present invention are particularly useful as an immunostimulating medicament capable to block proliferation or induce death in dividing cells such as tumor cells.
(FR)La présente invention concerne des particules comprenant de l'ARN, l'ARN étant associé à un polymère cationique ou à un lipide cationique, ou à la fois à un polymère cationique et un lipide cationique, l'ARN comprenant un nucléotide cytotoxique ou un analogue nucléotidique cytotoxique et/ou l'ARN étant lié de façon covalente à une cytotoxine, ainsi que des compositions pharmaceutiques contenant lesdites particules, et des utilisations pharmaceutiques des particules et des compositions pharmaceutiques. Les particules de la présente invention sont particulièrement utiles en tant que médicament immunostimulant capable de bloquer la prolifération ou induire la mort cellulaire de cellules en division telles que des cellules tumorales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)