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1. (WO2017067510) POLYPEPTIDE AND APPLICATION THEREOF IN PREPARING DRUG FOR TUMOR TREATMENT AND PREVENTION

Pub. No.:    WO/2017/067510    International Application No.:    PCT/CN2016/102897
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Oct 22 01:59:59 CEST 2016
IPC: C07K 7/06
A61K 38/08
A61P 35/00
A61P 35/02
Applicants: HU, Zhuowei
胡卓伟
Inventors: HU, Zhuowei
胡卓伟
HUA, Fang
花芳
LI, Ke
李珂
Title: POLYPEPTIDE AND APPLICATION THEREOF IN PREPARING DRUG FOR TUMOR TREATMENT AND PREVENTION
Abstract:
Disclosed in the present invention are a polypeptide specifically binding to tribbles homologue 3 (TRB3) and an application thereof in preparing a drug for tumor treatment and prevention. An amino acid sequence of the polypeptide is shown in sequence table SEQ ID No.8 as substituting two or more amino acids in the amino acid sequence with unnatural amino acids linking other side chains. The polypeptide can specifically bind to TRB3 so as to block the interaction between TRB3 and P62 proteins, and thus is applied in the preparation of a drug for tumor treatment and prevention. The prepared drug has significant curative effect in treating tumor diseases, fewer side effects and is safe to use.