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1. (WO2017067110) USE OF NADPH IN PREPARATION OF PLATELET AGGREGATION INHIBITORS

Pub. No.:    WO/2017/067110    International Application No.:    PCT/CN2016/071727
Publication Date: Fri Apr 28 01:59:59 CEST 2017 International Filing Date: Sat Jan 23 00:59:59 CET 2016
IPC: A61K 31/7084
A61P 7/02
Applicants: CHONGQING INSTITUTE OF BENCH-TO-BED BIOENGINEERING TECHNOLOGY CO., LTD.
重庆本贝得生物工程技术研究院有限公司
Inventors: QIN, Zhenghong
秦正红
LI, Mei
李梅
Title: USE OF NADPH IN PREPARATION OF PLATELET AGGREGATION INHIBITORS
Abstract:
Use of NADPH in preparation of platelet aggregation inhibitors. according to the research, it is found that in-vitro administration of exogenous NADPH inhibits ADP-induced platelet aggregation of rats in a dose-dependent mode; in-vitro administration of exogenous NADPH inhibits Thrombin-induced platelet aggregation of rats in a dose-dependent mode; preventive administration of NADPH in the rats can remarkably inhibit ADP-induced platelet aggregation; preventive administration of NADPH in the rats can remarkably inhibit Thrombin-induced platelet aggregation. Therefore, NADPH has a platelet aggregation inhibition function and can be used as a potential platelet aggregation inhibitor.