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Machine translation
1. (WO2017066964) OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/066964    International Application No.:    PCT/CN2015/092563
Publication Date: 27.04.2017 International Filing Date: 22.10.2015
IPC:
C07D 413/10 (2006.01), C07D 413/14 (2006.01), C07D 263/20 (2006.01), C07D 263/24 (2006.01), A61K 31/422 (2006.01), A61K 31/421 (2006.01), A61P 31/06 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway New Jersey 07065 (US).
YANG, Lihu [US/US]; (US) (US only).
OLSEN, David B. [US/US]; (US) (US only).
YOUNG, Katherine [US/US]; (US) (US only).
SU, Jing [US/US]; (US) (US only).
MANDAL, Mihir B. [US/US]; (US) (US only).
SUZUKI, Takao [JP/CN]; (CN) (US only).
YOU, Lanying [CN/CN]; (CN) (US only)
Inventors: YANG, Lihu; (US).
OLSEN, David B.; (US).
YOUNG, Katherine; (US).
SU, Jing; (US).
MANDAL, Mihir B.; (US).
SUZUKI, Takao; (CN).
YOU, Lanying; (CN)
Agent: WU, FENG & ZHANG CO.; Room 305, Tower B, Beijing Aerospace Cpmiec Building No 30, Haidian South Road, Haidian District Beijing 100080 (CN)
Priority Data:
Title (EN) OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS
(FR) COMPOSÉS OXAZOLIDINONE ET PROCÉDÉS D'UTILISATION DE CES DERNIERS EN TANT QU'AGENTS ANTIBACTÉRIENS
Abstract: front page image
(EN)The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosiscomprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or apharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
(FR)La présente invention concerne des composés oxazolidinone de formule (I) : et des sels pharmaceutiquement acceptables de ces derniers, dans ladite formule, A, E et R1 sont tels que définis dans la description. La présente invention concerne également des compositions qui comprennent au moins un composé oxazolidinone de la présente invention. L'invention concerne également des procédés permettant d'inhiber la croissance de cellules mycobactériennes ainsi qu'un procédé de traitement des infections mycobactériennes à Mycobacterium tuberculosis comprenant l'administration d'une quantité thérapeutiquement efficace d'une oxazolidinone de la présente invention et/ou d'un sel pharmaceutiquement acceptable de cette dernière, ou d'une composition comprenant ce composé et/ou ce sel.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)