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1. (WO2017066962) DOUBLE-TARGET MUTEIN MUR5S4TR OF TRAIL, AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/066962 International Application No.: PCT/CN2015/092560
Publication Date: 27.04.2017 International Filing Date: 22.10.2015
IPC:
C07K 19/00 (2006.01) ,C07K 14/525 (2006.01) ,C12N 15/28 (2006.01) ,C12N 15/70 (2006.01) ,A61K 38/17 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
525
Tumour necrosis factor (TNF)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
19
Interferons; Lymphokines; Cytokines
28
Tumor necrosis factors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70
Vectors or expression systems specially adapted for E. coli
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: CHENGDU HUACHUANG BIOTECHNOLOGY CO., LTD[CN/CN]; Room 409, Building C1, Tianfu Life Sci-Tech. Park, No.88, Keyuan South Road, Hi-and-New Tech Park Chengdu, Sichuan 610041, CN
Inventors: CHEN, Shouchun; CN
XU, Qi; CN
YAN, Juan; CN
HUANG, Xianzhou; CN
WEI, Lijia; CN
HU, Haiyang; CN
Agent: BEIJING UTC LIANFENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); Floor 1-4, Building A9-A10, No. 231-233, Science Avenue Economic & Technological Development District Guangzhou, Guangdong 510000, CN
Priority Data:
Title (EN) DOUBLE-TARGET MUTEIN MUR5S4TR OF TRAIL, AND PREPARATION METHOD AND USE THEREOF
(FR) MUTÉINE MUR5S4TR DE TRAIL À DOUBLE CIBLE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一种TRAIL双靶点突变蛋白MuR5S4TR、其制备方法及其应用
Abstract:
(EN) The present invention belongs to the field of genetic engineering drugs, and provides a mutein MuR5S4TR of TRAIL, and a preparation method and use thereof. The N-terminal positions 2-10 of the amino acid sequence of the mutein consist of the transmembrane peptide sequence RRRRR (R5) and the binding sequence AVPI of the apoptosis inhibitor XIAP, the positions 11-169 are the TRAIL protein peptide segment (123-281 aa), and the specific sequence is as shown in SEQ ID NO: 2.
(FR) La présente invention relève du domaine des médicaments fabriqués par génie génétique et concerne une mutéine MuR5S4TR de TRAIL, ainsi que son procédé de préparation et son utilisation. Les positions N-terminales 2 à 10 de la séquence d'acides aminés de la mutéine sont constituées de la séquence de peptide transmembranaire RRRRR (R5) et de la séquence de liaison AVPI de l'inhibiteur de l'apoptose XIAP, les positions 11 à 169 sont le segment peptidique (123-281 aa) de TRAIL, et la séquence spécifique est telle que représentée en séquence SEQ ID NO: 2.
(ZH) 本发明属于基因工程药物领域,提供了一种TRAIL的突变蛋白MuR5S4TR、其制备方法及用途。该突变蛋白氨基酸序列N端的第2-10位由穿膜肽序列RRRRR(R5)和凋亡抑制因子XIAP的结合序列AVPI组成,第11-169位为TRAIL蛋白肽段(123-281 aa),具体序列如SEQ ID NO:2所示。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)