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1. (WO2017066782) HYDROPHOBIC MRNA CAP ANALOGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/066782    International Application No.:    PCT/US2016/057385
Publication Date: 20.04.2017 International Filing Date: 17.10.2016
IPC:
C07H 1/00 (2006.01), C07H 19/207 (2006.01), C07H 19/20 (2006.01), C12Q 1/68 (2006.01), C07H 21/02 (2006.01)
Applicants: MODERNATX, INC. [US/US]; 200 Technology Square Cambridge, Massachusetts 02139 (US)
Inventors: BUTORA, Gabor; (US).
STANTON, Matthew; (US).
MIRACCO, Edward J.; (US)
Agent: ERLACHER, Heidi A.; (US).
OUYANG, Lian; (US)
Priority Data:
62/242,870 16.10.2015 US
Title (EN) HYDROPHOBIC MRNA CAP ANALOGS
(FR) ANALOGUES DE COIFFES D'ARNM HYDROPHOBES
Abstract: front page image
(EN)The present disclosure relates to cap analogs of formula (I), which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
(FR)La présente invention concerne des analogues de coiffes de formule (I), qui peuvent conduire à des niveaux élevés d'efficacité de coiffage et de transcription et de meilleurs rendements de traduction. La présente invention concerne également des procédés utiles pour la préparation d'analogues de coiffes et l'utilisation d'espèces d'ARNm contenant lesdits analogues, ainsi que des trousses contenant les nouveaux analogues de coiffes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)