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1. (WO2017066782) HYDROPHOBIC MRNA CAP ANALOGS

Pub. No.:    WO/2017/066782    International Application No.:    PCT/US2016/057385
Publication Date: Fri Apr 21 01:59:59 CEST 2017 International Filing Date: Tue Oct 18 01:59:59 CEST 2016
IPC: C07H 1/00
C07H 19/207
C07H 19/20
C12Q 1/68
C07H 21/02
Applicants: MODERNATX, INC.
Inventors: BUTORA, Gabor
STANTON, Matthew
MIRACCO, Edward J.
Title: HYDROPHOBIC MRNA CAP ANALOGS
Abstract:
The present disclosure relates to cap analogs of formula (I), which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.