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1. (WO2017066764) MODIFICATION OF N-TERMINAL REGION OF CAPSID PROTEINS FOR ENHANCED PROPERTIES OF ADENO-ASSOCIATED VIRUSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/066764    International Application No.:    PCT/US2016/057349
Publication Date: 20.04.2017 International Filing Date: 17.10.2016
IPC:
A61K 35/76 (2015.01), C07K 14/005 (2006.01), C12N 15/861 (2006.01), C12N 15/864 (2006.01)
Applicants: WILLIAM MARSH RICE UNIVERSITY [US/US]; 6100 Main Street Houston, TX 77005 (US)
Inventors: HO, Michelle; (US).
SUH, Junghae; (US).
YAMAGAMI, Momona; (US).
GOUGH, Veronica; (US)
Agent: COX, Ryan, P.; (US)
Priority Data:
62/242,378 16.10.2015 US
Title (EN) MODIFICATION OF N-TERMINAL REGION OF CAPSID PROTEINS FOR ENHANCED PROPERTIES OF ADENO-ASSOCIATED VIRUSES
(FR) MODIFICATION DE LA RÉGION N-TERMINALE DES PROTÉINES DE CAPSIDES POUR AMÉLIORER LES PROPRIÉTÉS DES VIRUS ADÉNO-ASSOCIÉS
Abstract: front page image
(EN)The present disclosure provide viral compositions and methods for modulating adeno- associated virus properties including transduction efficiency, virus capsid assembly, viral genome packaging, capsid stability and intracellular processing. Engineered adeno-associated viruses with modifications in the N-terminal region of the capsid proteins VPl or VP2 are provided which have varying effects on viral properties including transduction efficiency. Corresponding nucleic acids and amino acids are provided.
(FR)La présente divulgation concerne des compositions virales et des procédés permettant de moduler les propriétés des virus adéno-associés dont l'efficacité de transduction, l'assemblage de la capside du virus, l'encapsulation du génome viral, la stabilité de la capside et le traitement intracellulaire. Des virus adéno-associés génétiquement modifiés portant des modifications dans la région N-terminale des protéines de capsides VP1 ou VP2 ayant des effets variables sur les propriétés virales dont l'efficacité de la transduction sont en outre décrits. La présente divulgation concerne également les acides nucléiques et les acides aminés correspondants.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)