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1. (WO2017066763) PROTEASOME INHIBITORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/066763    International Application No.:    PCT/US2016/057346
Publication Date: 20.04.2017 International Filing Date: 17.10.2016
IPC:
F26B 17/04 (2006.01), B65G 19/28 (2006.01), A61K 39/00 (2006.01)
Applicants: CORNELL UNIVERSITY [US/US]; 395 Pine Tree Road, Suite 310 Center For Technology Licensing At Cornell University (CTL) Ithaca, NY 14850 (US)
Inventors: LIN, Gang; (US).
NATHAN, Carl; (US).
SINGH, Pradeep, K.; (US).
SHI, Lei; (US).
KIRKMAN, Laura; (US)
Agent: TISCHNER, Tate, L.; (US).
JONES, Shelley, A.; (US).
O'GARA, Megan, Thisse; (US).
GOLDMAN, Michael, L.; (US).
CHILDS, Carissa, R.; (US)
Priority Data:
62/242,139 15.10.2015 US
Title (EN) PROTEASOME INHIBITORS AND USES THEREOF
(FR) INHIBITEURS DES PROTÉASOMES ET LEURS UTILISATIONS
Abstract: front page image
(EN)The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R1 -R5, k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.
(FR)La présente invention concerne des composés représentés par les composés suivants répondant à la formule (I) : où les substituants R, R1-R5, k, m, n, et q sont tels que définis dans la description. Ces composés sont utiles dans le traitement du cancer, des troubles immunologiques, des troubles auto-immuns, des troubles neurodégénératifs ou des troubles inflammatoires, ou pour procurer une immunosuppression aux organes ou aux tissus greffés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)