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1. (WO2017066763) PROTEASOME INHIBITORS AND USES THEREOF
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Pub. No.: WO/2017/066763 International Application No.: PCT/US2016/057346
Publication Date: 20.04.2017 International Filing Date: 17.10.2016
IPC:
F26B 17/04 (2006.01) ,B65G 19/28 (2006.01) ,A61K 39/00 (2006.01)
F MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
26
DRYING
B
DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
17
Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement
02
with movement performed by belts carrying the materials; with movement performed by belts propelling the materials over stationary surfaces
04
the belts being all horizontal or slightly inclined
B PERFORMING OPERATIONS; TRANSPORTING
65
CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
G
TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
19
Conveyers comprising an impeller or a series of impellers carried by an endless traction element and arranged to move articles or materials over a supporting surface or underlying material, e.g. endless scraper conveyers
18
Details
28
Troughs, channels, or conduits
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
CORNELL UNIVERSITY [US/US]; 395 Pine Tree Road, Suite 310 Center For Technology Licensing At Cornell University (CTL) Ithaca, NY 14850, US
Inventors:
LIN, Gang; US
NATHAN, Carl; US
SINGH, Pradeep, K.; US
SHI, Lei; US
KIRKMAN, Laura; US
Agent:
TISCHNER, Tate, L.; US
JONES, Shelley, A.; US
O'GARA, Megan, Thisse; US
GOLDMAN, Michael, L.; US
CHILDS, Carissa, R.; US
Priority Data:
62/242,13915.10.2015US
Title (EN) PROTEASOME INHIBITORS AND USES THEREOF
(FR) INHIBITEURS DES PROTÉASOMES ET LEURS UTILISATIONS
Abstract:
(EN) The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R1 -R5, k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.
(FR) La présente invention concerne des composés représentés par les composés suivants répondant à la formule (I) : où les substituants R, R1-R5, k, m, n, et q sont tels que définis dans la description. Ces composés sont utiles dans le traitement du cancer, des troubles immunologiques, des troubles auto-immuns, des troubles neurodégénératifs ou des troubles inflammatoires, ou pour procurer une immunosuppression aux organes ou aux tissus greffés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)