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1. (WO2017066643) P-ETHOXY NUCLEIC ACIDS FOR LIPOSOMAL FORMULATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/066643 International Application No.: PCT/US2016/057148
Publication Date: 20.04.2017 International Filing Date: 14.10.2016
IPC:
C12N 15/113 (2010.01)
Applicants: BIO-PATH HOLDINGS, INC.[US/US]; 4710 Bellaire Blvd., Suite 210 Bellaire, TX 77401, US
Inventors: NIELSEN, Peter; US
Agent: SCHNEPP, Amanda, S.J.; US
Priority Data:
62/241,50314.10.2015US
Title (EN) P-ETHOXY NUCLEIC ACIDS FOR LIPOSOMAL FORMULATION
(FR) ACIDES P-ÉTHOXYNUCLÉIQUES POUR UNE FORMULATION LIPOSOMALE
Abstract:
(EN) Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.
(FR) La présente invention concerne des oligonucléotides thérapeutiques qui comprennent au moins une liaison p-éthoxy-squelette mais pas plus de 80 % de liaisons p-éthoxy-squelette. La présente invention concerne des systèmes d'administration améliorés pour des oligonucléotides thérapeutiques comprenant un liposome qui comprend des phospholipides neutres et un p-éthoxy-oligonucléotide qui est piégé dans le liposome.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)