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1. (WO2017066583) A NANOMATERIAL COMPLEX COMPRISING GRAPHENE OXIDE ASSOCIATED WITH A THERAPEUTIC AGENT AND METHODS OF USE
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Pub. No.: WO/2017/066583 International Application No.: PCT/US2016/057060
Publication Date: 20.04.2017 International Filing Date: 14.10.2016
IPC:
A61K 39/395 (2006.01) ,A61K 39/44 (2006.01) ,A61K 47/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44
Antibodies bound to carriers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION[US/US]; 615 Arapeen Drive Suite 310 Salt Lake City, UT 84108, US
Inventors: CHEN, Xinjian; US
LUO, Chengke; CN
JENSEN, Peter; US
LAN, Li; CN
WELM, Alana; US
Agent: MARTY, Scott, D.; US
CHOI, Wendy, A.; US
MEADOWS, Brian, C.; US
NEEDLE, William, H.; US
KATZ, Mitchell, A.; US
Priority Data:
62/242,56416.10.2015US
62/315,42230.03.2016US
Title (EN) A NANOMATERIAL COMPLEX COMPRISING GRAPHENE OXIDE ASSOCIATED WITH A THERAPEUTIC AGENT AND METHODS OF USE
(FR) COMPLEXES DE NANOMATÉRIAUX COMPRENANT DE L'OXYDE DE GRAPHÈNE ASSOCIÉ À UN AGENT THÉRAPEUTIQUE ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) Disclosed herein, are compositions comprising one or more therapeutic agents non- covalently conjugated to a nanomaterial (e.g., graphene oxide). Also, described herein, are methods of preparing stable compositions, the methods comprising a plurality of antibodies non-covalently bound to graphene oxide; physiologically acceptable compositions including them; and methods of administering the compositions to patients for the treatment of a disease such as cancer and autoimmune disorders as well as for the prevention of graft rejection.
(FR) L'invention concerne des compositions comprenant un ou plusieurs agents thérapeutiques conjugués par liaison non covalente à un nanomatériau (par exemple, l'oxyde de graphène). En outre, l'invention concerne des procédés de préparation de compositions stables, les procédés comprenant une pluralité d'anticorps liés par liaison non covalente à l'oxyde de graphène ; des compositions physiologiquement acceptables les comprenant ; et des procédés d'administration des compositions à des patients pour traiter une maladie telle que le cancer et des troubles auto-immuns ainsi que pour la prévention du rejet de greffe.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)