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1. (WO2017066561) REGULATORY T CELL PD-1 MODULATION FOR REGULATING T CELL EFFECTOR IMMUNE RESPONSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/066561    International Application No.:    PCT/US2016/057031
Publication Date: 20.04.2017 International Filing Date: 14.10.2016
IPC:
A61K 35/17 (2015.01), G01N 33/50 (2006.01), A61K 39/395 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US).
SHARPE, Arlene, H. [US/US]; (US).
FREEMAN, Gordon, J. [US/US]; (US).
FRANCISCO, Loise, M. [US/US]; (US).
SAGE, Peter, T. [US/US]; (US).
LEE, Sun, J. [US/US]; (US).
LOVITCH, Scott, B. [US/US]; (US).
JUNEJA, Vikram, R. [US/US]; (US).
TAN, Catherine, L. [US/US]; (US)
Inventors: SHARPE, Arlene, H.; (US).
FREEMAN, Gordon, J.; (US).
FRANCISCO, Loise, M.; (US).
SAGE, Peter, T.; (US).
LEE, Sun, J.; (US).
LOVITCH, Scott, B.; (US).
JUNEJA, Vikram, R.; (US).
TAN, Catherine, L.; (US)
Agent: SMITH, DeAnn, F.; (US).
CHOI, Philip, S.; (US).
ABELLEIRA, Susan, M.; (US).
BLOUNT, Jennifer, V.; (US).
AKHIEZER, Alexander; (US)
Priority Data:
62/242,509 16.10.2015 US
Title (EN) REGULATORY T CELL PD-1 MODULATION FOR REGULATING T CELL EFFECTOR IMMUNE RESPONSES
(FR) MODULATION DE PD-1 DES LYMPHOCYTES T RÉGULATEURS POUR RÉGULER LES RÉPONSES IMMUNITAIRES EFFECTRICES DES LYMPHOCYTES T
Abstract: front page image
(EN)The present invention is based, in part, on the identification of methods of modulating PD-1 expression and/or activity in regulatory T cells (Tregs) to thereby regulate effector immune responses in effector T cells (Teffs).
(FR)La présente invention est basée, en partie, sur l'identification de méthodes de modulation de l'expression et/ou de l'activité de PD-1 dans des lymphocytes T régulateurs (Tregs) pour ainsi réguler les réponses immunitaires effectrices dans des lymphocytes T effecteurs (Teff).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)