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1. (WO2017066554) STABLE PROTEIN COMPOSITIONS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/066554 International Application No.: PCT/US2016/057019
Publication Date: 20.04.2017 International Filing Date: 14.10.2016
IPC:
A61K 9/00 (2006.01) ,A61K 9/14 (2006.01) ,A61K 9/19 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
19
lyophilised
Applicants: REGENERON PHARMACEUTICALS, INC.[US/US]; 777 Old Saw Mill River Road Tarrytown, New York 10591, US
Inventors: CHEN, Hunter; US
SCHLESINGER, Erica; US
Agent: KIRSCH, Gregory J.; US
Priority Data:
62/242,41216.10.2015US
Title (EN) STABLE PROTEIN COMPOSITIONS
(FR) COMPOSITIONS PROTÉINIQUES STABLES
Abstract:
(EN) Stable pharmaceutical formulations and drug delivery devices are disclosed. In certain embodiments, the drug delivery device contains a reservoir when implanted into a patient is in partial contact with the tissue environment. The reservoir remains in contact with the environment via a porous structure in the housing of the delivery device. The reservoir contains a combination of the therapeutic biomolecule and a second molecule that serves to stabilize and restrict the solubility of the therapeutic biomolecule, thereby controlling the amount of therapeutic biomolecule that is in solution. The concentration of the soluble therapeutic biomolecule or the size of the surface area of the porous structure controls the rate of delivery of the therapeutic biomolecule to the target tissue.
(FR) La présente invention concerne des formulations pharmaceutiques stables et des dispositifs d'administration de médicaments. Dans certains modes de réalisation, le dispositif d'administration de médicaments contient un réservoir qui, lorsqu'il est implanté dans un patient, est partiellement en contact avec l'environnement du tissu. Le réservoir reste en contact avec l'environnement par l'intermédiaire d'une structure poreuse dans le logement du dispositif d'administration. Le réservoir contient une association de la biomolécule thérapeutique et d'une seconde molécule qui sert à stabiliser et à limiter la solubilité de la biomolécule thérapeutique, ce qui permet de réguler la quantité de biomolécule thérapeutique qui est en solution. La concentration de la biomolécule thérapeutique soluble ou la taille de la surface de la structure poreuse régule la vitesse d'administration de la biomolécule thérapeutique au tissu cible.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)