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1. (WO2017066507) MULTI-LAYER AIRWAY ORGANOIDS AND METHODS OF MAKING AND USING THE SAME

Pub. No.:    WO/2017/066507    International Application No.:    PCT/US2016/056947
Publication Date: Fri Apr 21 01:59:59 CEST 2017 International Filing Date: Sat Oct 15 01:59:59 CEST 2016
IPC: C12N 5/071
C12N 5/00
C12M 1/00
C12M 3/00
Applicants: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventors: MURPHY, Sean V.
ATALA, Anthony
Title: MULTI-LAYER AIRWAY ORGANOIDS AND METHODS OF MAKING AND USING THE SAME
Abstract:
Provided herein are artificial lung organoids. The artificial lung organoids may include an epithelial cell layer comprising mammalian lung epithelial cells, a stromal cell layer comprising mammalian lung fibroblast cells and an endothelial cell layer comprising mammalian endothelial cells. The artificial lung organoids may optionally include a porous membrane between said epithelial cell layer and said stromal cell layer and/or between said stromal cell layer and said endothelial lung cell layer.