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1. (WO2017066497) GENOME ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS

Pub. No.:    WO/2017/066497    International Application No.:    PCT/US2016/056925
Publication Date: Fri Apr 21 01:59:59 CEST 2017 International Filing Date: Fri Oct 14 01:59:59 CEST 2016
IPC: C12N 15/867
C12N 15/86
C12N 15/09
C12N 9/22
C12N 5/10
A61K 48/00
Applicants: DUKE UNIVERSITY
NORTH CAROLINA STATE UNIVERSITY
Inventors: GERSBACH, Charles, A.
PICKAR, Adrian
BEISEL, Chase
Title: GENOME ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS
Abstract:
Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.