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1. (WO2017066481) CHIMERIC ANTIGEN RECEPTORS CONTAINING A CHLOROTOXIN DOMAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/066481    International Application No.:    PCT/US2016/056901
Publication Date: 20.04.2017 International Filing Date: 13.10.2016
IPC:
C07K 14/435 (2006.01), C07K 16/30 (2006.01), C12N 5/0783 (2010.01), C12N 15/62 (2006.01), A61K 35/17 (2015.01), A61P 35/00 (2006.01), C07K 14/705 (2006.01), C07K 14/725 (2006.01)
Applicants: CITY OF HOPE [US/US]; 1500 East Duarte Road Duarte, CA 91010 (US)
Inventors: BARISH, Michael; (US).
BROWN, Christine E.; (US).
FORMAN, Stephen J.; (US).
WANG, Dongrui; (--)
Agent: MEIKLEJOHN, PH.D., Anita L.; (US)
Priority Data:
62/241,021 13.10.2015 US
Title (EN) CHIMERIC ANTIGEN RECEPTORS CONTAINING A CHLOROTOXIN DOMAIN
(FR) RÉCEPTEURS D'ANTIGÈNES CHIMÉRIQUES CONTENANT UN DOMAINE CHLOROTOXINE
Abstract: front page image
(EN)Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes chlorotoxin or a related toxin, or a variant of chlorotoxin or a related toxin, that binds to human glioma or other human tumor cells, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
(FR)Cette invention concerne des immunorécepteurs transmembranaires chimériques (CAR) comprenant un domaine extracellulaire qui contient une chlorotoxine ou toxine apparentée, ou un variant de chlorotoxine ou d'une toxine apparentée, qui se lie au gliome humain ou à d'autres cellules tumorales humaines; une région transmembranaire; un domaine costimulateur et un domaine de signalisation intracellulaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)