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1. (WO2017066268) SUPERCAPACITOR-BASED BIOSENSORS AND METHODS OF DETECTING A BIOMARKER
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Pub. No.: WO/2017/066268 International Application No.: PCT/US2016/056570
Publication Date: 20.04.2017 International Filing Date: 12.10.2016
IPC:
G01N 27/00 (2006.01) ,G01N 33/543 (2006.01) ,C12Q 1/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
Applicants:
OHIO UNIVERSITY [US/US]; 340 West State Street, Unit 14 Athens, OH 45701, US
Inventors:
STASER, John, Adams; US
RODRIGUEZ, Allen, A.; US
CABRERA, Omar, A.; US
Agent:
CONKLIN, Elizabeth, A.; US
BENINTENDI, Steven, W.; US
BELLAMY, Glenn, D.; US
AHRENS, Gregory, F.; US
ARDIZZONE, Timothy, D.; US
Priority Data:
62/240,22512.10.2015US
Title (EN) SUPERCAPACITOR-BASED BIOSENSORS AND METHODS OF DETECTING A BIOMARKER
(FR) BIOCAPTEURS À SUPERCONDENSATEUR ET PROCÉDÉS DE DÉTECTION D'UN BIOMARQUEUR
Abstract:
(EN) A supercapacitor-based biosensor (10) for use in detecting a biomarker includes an electrode (12) coated with a nanocomposite film (14) including a nanostructured carbon material, such as graphene oxide, and a polymer containing amine functional groups, such as polyethylenimine. The coated electrode (12) is functionalized with an antibody (16) capable of binding with the biomarker. A method of fabricating a supercapacitor-based biosensor (10) includes functionalizing graphene oxide with polyethylenimine to create a nanocomposite, combining said nanocomposite with chitosan to form a blend, coating an electrode (12) with said blend to form a film (14), and functionalizing the film (14) with an antibody (16). A method of detecting a biomarker using a supercapacitor-based biosensor (10) includes adsorbing the biomarker on the supercapacitor-based biosensor (10), measuring a capacitance of the supercapacitor-based biosensor (10), and determining a concentration of adsorbed biomarker using the capacitance.
(FR) Un biocapteur (10) à supercondensateur à utiliser dans la détection d'un biomarqueur, comporte une électrode (12) revêtue d'un film nanocomposite (14) comprenant un matériau de carbone nanostructuré, tel que l'oxyde de graphène et un polymère contenant des groupes fonctionnels amine, telle que la polyéthylènimine. L'électrode revêtue (12) est fonctionnalisée avec un anticorps (16) capable de se lier avec le biomarqueur. L'invention concerne également un procédé de fabrication d'un biocapteur (10) à supercondensateur comprenant la fonctionnalisation d'oxyde de graphène avec de la polyéthylèneimine pour créer un nanocomposite, la combinaison dudit nanocomposite avec du chitosane pour former un mélange, le revêtement d'une électrode (12) dudit mélange pour former un film (14), et la fonctionnalisation du film (14) avec un anticorps (16). L'invention concerne en outre un procédé de détection d'un biomarqueur au moyen d'un biocapteur (10) à supercondensateur, comprenant l'adsorption du biomarqueur sur le biocapteur (10) à supercondensateur, la mesure d'une capacité d'un biocapteur (10) à supercondensateur, et la détermination d'une concentration de biomarqueur adsorbé au moyen de la capacité.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)