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1. (WO2017066193) NOVEL INHIBITORS OF PROTEIN KINASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/066193    International Application No.:    PCT/US2016/056439
Publication Date: 20.04.2017 International Filing Date: 11.10.2016
IPC:
A61K 31/437 (2006.01), C07D 471/04 (2006.01), A61P 35/00 (2006.01)
Applicants: PRINCETON DRUG DISCOVERY, LLC [US/US]; 9 Deepark Drive, Suite A-1 Monmouth Junction, NJ 08852 (US)
Inventors: HE, Kan; (US)
Agent: WOOLF, Thomas, F.; (US)
Priority Data:
62/241,903 15.10.2015 US
62/400,510 27.09.2016 US
Title (EN) NOVEL INHIBITORS OF PROTEIN KINASES
(FR) NOUVEAUX INHIBITEURS DE PROTÉINES KINASES
Abstract: front page image
(EN)Protein kinases are regulators of cellular signaling and their functional dysregulation is common in carcinogenesis and many other disease states or disorders. The present invention relates to novel chemical entities that have biological activity to modulate mammalian protein kinase enzymes. In particular, compounds of the invention display potent inhibition of breast tumor related kinase (BRK).
(FR)Les protéines kinases sont des régulateurs de signalisation cellulaire et leur dérèglement fonctionnel est commun en carcinogenèse et dans de nombreux autres troubles ou états pathologiques. La présente invention concerne de nouvelles entités chimiques qui ont une activité biologique pour moduler des enzymes de protéine kinase de mammifère. En particulier, des composés de l'invention présentent une inhibition puissante de kinase associée à une tumeur du sein (BRK).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)