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1. (WO2017065245) MEDICINAL COMPOSITION FOR AMELIORATING AND TREATING INTERVERTEBRAL DISC DEGENERATION AND LOW BACK PAIN, AND METHOD FOR SCREENING THERAPEUTIC AGENT

Pub. No.:    WO/2017/065245    International Application No.:    PCT/JP2016/080452
Publication Date: Fri Apr 21 01:59:59 CEST 2017 International Filing Date: Fri Oct 14 01:59:59 CEST 2016
IPC: A61K 45/00
A61K 31/198
A61K 31/355
A61P 19/02
Applicants: KEIO UNIVERSITY
学校法人 慶應義塾
Inventors: MATSUMOTO Morio
松本 守雄
NAKAMURA Masaya
中村 雅也
FUJITA Nobuyuki
藤田 順之
SUZUKI Satoshi
鈴木 悟士
NAKASHIMA Daisuke
中島 大輔
Title: MEDICINAL COMPOSITION FOR AMELIORATING AND TREATING INTERVERTEBRAL DISC DEGENERATION AND LOW BACK PAIN, AND METHOD FOR SCREENING THERAPEUTIC AGENT
Abstract:
It was found that N-acetylcysteine (NAC) and tocopherol are efficacious as a therapeutic agent for ameliorating intervertebral disc degeneration as well as low back pain and other diseases caused thereby. By clarifying that oxidation stress is one of the factors causing intervertebral disc degeneration, provided is a method for screening a drug for intervertebral disc degeneration and low back pain, said drug targeting oxidation stress. Also, a method for quantitatively evaluating intervertebral disc degeneration using MRI images is developed.