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1. (WO2017064221) MULTIVALENT FV ANTIBODIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/064221 International Application No.: PCT/EP2016/074642
Publication Date: 20.04.2017 International Filing Date: 13.10.2016
IPC:
C07K 16/28 (2006.01)
Applicants: AFFIMED GMBH[DE/DE]; Im Neuenheimer Feld 582 69120 Heidelberg, DE
Inventors: ELLWANGER, Kristina; DE
FUCEK, Ivica; DE
ROSS, Thorsten; DE
MUELLER, Thomas; DE
RAJKOVIC, Erich; DE
REUSCH, Uwe; DE
TREDER, Martin; DE
WEICHEL, Michael; DE
Agent: SCHÜSSLER, Andrea; DE
SCHMITZ, Georg; DE
Priority Data:
15189665.113.10.2015EP
Title (EN) MULTIVALENT FV ANTIBODIES
(FR) ANTICORPS FV POLYVALENTS
Abstract: front page image
(EN) Described is a trispecific antibody molecule comprising a diabody-unit integrated into a polypeptide chain having at least six variable domains linked one after another. In certain instances two single-chain Fv (scFv) fragments are distally connected to the diabody-unit providing two further antigen binding sites.
(FR) L'invention concerne une molécule d'anticorps trispécifique comprenant un motif d’anticorps bispécifique de type « diabody » intégré dans une chaîne polypeptidique possédant au moins six domaines variables reliés l'un après l'autre. Dans certains cas deux fragments de Fv monocaténaires (scFv) sont reliés d'une manière distale au motif d’anticorps bispécifique de type « diabody », ce qui fournit deux autres sites de liaison à l’antigène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)