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1. (WO2017064043) CD73 BLOCKING AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/064043    International Application No.:    PCT/EP2016/074306
Publication Date: 20.04.2017 International Filing Date: 11.10.2016
IPC:
C07K 16/28 (2006.01), C07K 16/40 (2006.01)
Applicants: INNATE PHARMA [FR/FR]; 117 Avenue de Luminy 13009 Marseille (FR).
CENTRE LÉON BÉRARD [FR/FR]; 28, Rue Laennec 69373 Lyon Cedex 08 (FR)
Inventors: CAUX, Christophe; (FR).
GAUTHIER, Laurent; (FR).
GOURDIN, Nicolas; (FR).
MENETRIER-CAUX, Christine; (FR).
PATUREL, Carine; (FR).
PERROT, Ivan; (FR)
Agent: VOLLMY, Lukas; (FR)
Priority Data:
62/240,101 12.10.2015 US
62/240,112 12.10.2015 US
Title (EN) CD73 BLOCKING AGENTS
(FR) AGENTS DE BLOCAGE DE CD73
Abstract: front page image
(EN)Provided are antibodies that bind and inhibit CD73, are capable of increasing the proliferation of T cells in the presence of CD39- expressing B cells and ATP. The disclosure also relates to cells producing such compounds; methods of making such compounds, and antibodies, fragments, variants, and derivatives thereof; pharmaceutical compositions comprising the same; methods of using the compounds to diagnose, treat or prevent cancer.
(FR)L'invention concerne des anticorps se liant à CD73 et l'inhibant, aptes à augmenter la prolifération de lymphocytes T en présence de lymphocytes B exprimant CD39 et d'ATP. L'invention concerne également des cellules produisant de tels composés; des procédés de fabrication de ces composés, ainsi que des anticorps, des fragments, des variants et des dérivés de ceux-ci; des compositions pharmaceutiques les contenant; des méthodes d'utilisation de ces composés dans le diagnostic, le traitement ou la prévention du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)