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1. (WO2017063572) NOVEL CRYSTAL FORM OF CELL APOPTOSIS INDUCING AGENT AND PREPARATION METHOD THEREOF
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Pub. No.: WO/2017/063572 International Application No.: PCT/CN2016/102022
Publication Date: 20.04.2017 International Filing Date: 13.10.2016
IPC:
C07D 471/04 (2006.01) ,A61K 31/496 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
苏州晶云药物科技有限公司 CRYSTAL PHARMATECH CO., LTD. [CN/CN]; 中国江苏省苏州市 苏州工业园区星湖街218号生物纳米园B4-101 B4-101, Biobay, 218 Xinghu Street, Suzhou Industrial Park Suzhou, Jiangsu 215123, CN
Inventors:
陈敏华 CHEN, Minhua; CN
张炎锋 ZHANG, Yanfeng; CN
陆飞 LU, Fei; CN
张晓宇 ZHANG, Xiaoyu; CN
Agent:
北京寰华知识产权代理有限公司 SINO-ELITE INTELLECTUAL PROPERTY AGENCY (BEIJING); 中国北京市 西城区宣武门外大街28号富卓大厦B1105室 B1105, TOP Office Center, No.28 Xuanwumenwai Avenue, Xicheng District Beijing 100052, CN
Priority Data:
201510660719.213.10.2015CN
Title (EN) NOVEL CRYSTAL FORM OF CELL APOPTOSIS INDUCING AGENT AND PREPARATION METHOD THEREOF
(FR) NOUVELLE FORME CRISTALLINE D'AGENT INDUISANT L'APOPTOSE DE CELLULES ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 细胞凋亡诱导剂的新晶型及其制备方法
Abstract:
(EN) The present invention relates to novel crystalline forms of a cell apoptosis inducing agent and a preparation method therefor, the structural formula whereof is shown in formula (I). The crystalline forms are obtained directly from the solvent by crystallization, and have a good stability, low wetting and uniform particle size distribution, and provide a new and improved choice for the preparation of pharmaceutical preparations containing ABT199, and are of great significance for drug development.
(FR) La présente invention concerne une nouvelle forme cristalline d'un agent induisant l'apoptose de cellules et son procédé de préparation, la formule développée de cette dernière étant tel qu'indiqué dans la formule (I). Ces cristaux peuvent être obtenus directement à partir du solvant par cristallisation, et présentent une bonne stabilité, un faible mouillage et une distribution uniforme de la taille des particules, et procurent un nouveau choix, meilleur, pour la préparation de préparations pharmaceutiques contenant de l'ABT199, et sont d'une grande importance pour la mise au point de médicaments.
(ZH) 本发明涉及一种细胞凋亡诱导剂的新晶型及其制备方法,其结构式如式(I)所示,这些晶型能够直接从溶剂中析晶得到,且稳定性良好、引湿性低、粒度分布均一,为含ABT199的药物制剂的制备提供了新的更好的选择,对于药物开发具有非常重要的意义。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)