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1. (WO2017063542) STABILIZED A7R POLYPEPTIDES, AND USE THEREOF IN CONSTRUCTING TUMOR TARGETED THERAPEUTIC DRUG DELIVERY SYSTEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/063542    International Application No.:    PCT/CN2016/101738
Publication Date: 20.04.2017 International Filing Date: 11.10.2016
IPC:
C07K 7/06 (2006.01), A61K 47/34 (2017.01), A61K 47/42 (2017.01), A61K 49/00 (2006.01), A61P 35/00 (2006.01), C07K 7/64 (2006.01)
Applicants: FUDAN UNIVERSITY [CN/CN]; 220 Handan Road, Yangpu District Shanghai 201203 (CN)
Inventors: LU, Weiyue; (CN).
YING, Man; (CN).
XIE, Cao; (CN).
GAO, Jie; (CN).
SONG, Xianfei; (CN).
LI, Xue; (CN).
ZHANG, Mingfei; (CN)
Agent: INNOWISE INTELLECTUAL PROPERTY LAW OFFICE; Liu Danni, Suite 708, Tower B Zhucheng Building No. A 6 Zhong Guan Cun South Road Haidian District, Beijing 100086 (CN)
Priority Data:
201510653735.9 12.10.2015 CN
201610150524.8 16.03.2016 CN
Title (EN) STABILIZED A7R POLYPEPTIDES, AND USE THEREOF IN CONSTRUCTING TUMOR TARGETED THERAPEUTIC DRUG DELIVERY SYSTEM
(FR) POLYPEPTIDES A7R STABILISÉS, ET UTILISATION DE CES DERNIERS DANS LA CONSTRUCTION D'UN SYSTÈME D'ADMINISTRATION DE MÉDICAMENT THÉRAPEUTIQUE CIBLANT LES TUMEURS
(ZH) 稳定化A7R多肽及其在构建肿瘤靶向诊治递药系统中的用途
Abstract: front page image
(EN)Provided are a retro-inverso polypeptides, DA7R, and a head-to-tail cyclized polypeptides with an amide bond, cA7R, having a high binding activity with vascular endothelial growth factor receptor-2 and neuropilin-1, and said polypeptides have an anti-tumor effect. Also provided are a composite of the polypeptides with a fluorescein, a drug, or a polymer carrier material, a preparation method thereof, and a use thereof in tumor imaging and targeted therapeutic drug delivery system construction.
(FR)L'invention concerne des polypeptides rétro-inverso, DA7R, et des polypeptides tête-à-queue cyclisés ayant une liaison amide, cA7R, présentant une forte activité de liaison avec le récepteur 2 du facteur de croissance endothéliale vasculaire et la neuropiline 1, et lesdits polypeptides ont un effet anti-tumoral. L'invention concerne également un composite de ces polypeptides avec une fluorescéine, un médicament, ou un matériau support polymère, un procédé de préparation de ce dernier, et une utilisation de ce dernier dans l'imagerie tumorale et la construction d'un système d'administration de médicament thérapeutique ciblé.
(ZH)提供了一种与血管内皮生长因子受体2和神经纤毛蛋白-1高结合活性的逆序D构型多肽DA7R和首尾酰胺键环合多肽cA7R,所述多肽可抗肿瘤。还提供了所述多肽与荧光素、药物、高分子载体材料复合物及其制备方法,以及在肿瘤影像和靶向治疗用递药系统构建中的应用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)