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1. (WO2017063196) C-REL-SPECIFIC SIRNA AND APPLICATION THEREOF FOR TREATING AUTOIMMUNE PSORIASIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2017/063196    International Application No.:    PCT/CN2015/092124
Publication Date: 20.04.2017 International Filing Date: 16.10.2015
IPC:
C12N 15/11 (2006.01), A61K 48/00 (2006.01)
Applicants: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY [CN/CN]; No. 1068 Xueyuan Avenue, Xili University Town, Nanshan District Shenzhen, Guangdong 518055 (CN).
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3451 Walnut Street Philadelphia, Pennsylvania 19104 (US)
Inventors: RUAN, Qingguo; (CN).
CHEN, Youhai H.; (US).
FAN, Tingting; (CN).
MA, Yifan; (CN).
CAI, Lintao; (CN).
WANG, Shaowen; (CN).
WAN, Xiaochun; (CN)
Agent: BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD.; 16th Fl.,Block A,Corporate Square No. 35 Jinrong Street Beijing 100033 (CN)
Priority Data:
Title (EN) C-REL-SPECIFIC SIRNA AND APPLICATION THEREOF FOR TREATING AUTOIMMUNE PSORIASIS
(FR) ARNSI SPÉCIFIQUE DE C-REL ET APPLICATION ASSOCIÉE POUR LE TRAITEMENT DU PSORIASIS AUTO-IMMUN
(ZH) c-Rel特异性siRNA及其用于防治自身免疫性银屑病的应用
Abstract: front page image
(EN)Provided is a c-Rel-specific siRNA and an application thereof for treating autoimmune psoriasis. Specifically, the c-Rel-specific siRNA has a sequence such as SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. The present invention adopts a c-Rel-specific small interfering RNA to suppress biosynthesis of c-Rel, and treats autoimmune psoriasis by suppressing IL-23/IL-17A inflammatory axis-related inflammation factors.
(FR)L'invention concerne un ARNsi spécifique de c-Rel et une application associée pour le traitement du psoriasis auto-immun. Spécifiquement, l'ARNsi spécifique de c-Rel comprend une séquence telle que SEQ ID NO : 1-2 ou SEQ ID NO : 3-4. La présente invention adopte un petit ARN interférent spécifique de c-Rel pour supprimer la biosynthèse de c-Rel, et traite le psoriasis auto-immun par suppression des facteurs d'inflammation liés à l'axe inflammatoire IL -23/IL-17A.
(ZH)提供了c-Rel特异性siRNA及其用于防治自身免疫性银屑病的应用。具体而言,所述c-Rel特异性siRNA具有如SEQ ID Nos.1~2或SEQ ID Nos.3~4所示序列,本发明采用c-Rel特异的小干扰核糖核酸来抑制c-Rel的生物合成,并通过抑制IL-23/IL-17A炎症轴相关炎症因子来防治自身免疫性银屑病。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)