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|1. (WO2017062855) NOVEL RNA-GUIDED NUCLEASES AND USES THEREOF|
|Applicants:||MONSANTO TECHNOLOGY LLC
|Inventors:||CHITTOOR, Jaishree M.
NAGY, Ervin D.
TURNER, Keith H.
|Title:||NOVEL RNA-GUIDED NUCLEASES AND USES THEREOF|
Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for cleaving a target DNA in eukaryotic cells with a guide RNA capable of hybridizing with a target sequence and an RNA-guided DNA nuclease are provided. Also provided are vectors and vector systems which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR systems.