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1. (WO2017062855) NOVEL RNA-GUIDED NUCLEASES AND USES THEREOF

Pub. No.:    WO/2017/062855    International Application No.:    PCT/US2016/056115
Publication Date: Fri Apr 14 01:59:59 CEST 2017 International Filing Date: Sat Oct 08 01:59:59 CEST 2016
IPC: C12N 5/00
C12N 5/04
C12N 9/22
C12N 15/05
C12N 15/00
C12N 15/63
C12N 15/74
C12N 15/82
C12N 15/90
C12N 15/113
C12P 19/34
Applicants: MONSANTO TECHNOLOGY LLC
Inventors: CHITTOOR, Jaishree M.
NAGY, Ervin D.
TURNER, Keith H.
Title: NOVEL RNA-GUIDED NUCLEASES AND USES THEREOF
Abstract:
Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for cleaving a target DNA in eukaryotic cells with a guide RNA capable of hybridizing with a target sequence and an RNA-guided DNA nuclease are provided. Also provided are vectors and vector systems which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR systems.