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1. (WO2017062818) STABILIZED ASSEMBLED NANOSTRUCTURES FOR DELIVERY OF ENCAPSULATED AGENTS

Pub. No.:    WO/2017/062818    International Application No.:    PCT/US2016/056070
Publication Date: Fri Apr 14 01:59:59 CEST 2017 International Filing Date: Sat Oct 08 01:59:59 CEST 2016
IPC: A61K 9/00
A61K 47/14
A61K 47/22
A61K 47/24
A61K 47/26
A61K 47/28
A61K 9/107
A61K 9/127
A61K 31/00
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventors: KARP, Jeffrey
JOSHI, Nitin
WIRADHARMA, Nikken
SLAUGHTER, Kai, Vincent
Title: STABILIZED ASSEMBLED NANOSTRUCTURES FOR DELIVERY OF ENCAPSULATED AGENTS
Abstract:
A non-covalently assembled hydrogel or organo-gel composition with serum stability is described. Low molecular weight (<2,500 Da), generally regarded as safe (GRAS), materials assemble in the presence of a stabilizing agent at an appropriate molar percentage, forming hydrogel or organo-gel with nanostructures that resist disassembly or destabilization in serum for an extended period of time. The composition is used to deliver one or more therapeutic, prophylactic, or diagnostic agents, allowing for controlled release in response to biological stimuli such as enzymes and a greatly improved dosing efficacy.