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|1. (WO2017062818) STABILIZED ASSEMBLED NANOSTRUCTURES FOR DELIVERY OF ENCAPSULATED AGENTS|
|Applicants:||THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
SLAUGHTER, Kai, Vincent
|Title:||STABILIZED ASSEMBLED NANOSTRUCTURES FOR DELIVERY OF ENCAPSULATED AGENTS|
A non-covalently assembled hydrogel or organo-gel composition with serum stability is described. Low molecular weight (<2,500 Da), generally regarded as safe (GRAS), materials assemble in the presence of a stabilizing agent at an appropriate molar percentage, forming hydrogel or organo-gel with nanostructures that resist disassembly or destabilization in serum for an extended period of time. The composition is used to deliver one or more therapeutic, prophylactic, or diagnostic agents, allowing for controlled release in response to biological stimuli such as enzymes and a greatly improved dosing efficacy.