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1. (WO2017062804) CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF

Pub. No.:    WO/2017/062804    International Application No.:    PCT/US2016/056051
Publication Date: Fri Apr 14 01:59:59 CEST 2017 International Filing Date: Sat Oct 08 01:59:59 CEST 2016
IPC: A61K 31/4375
C07D 455/03
Applicants: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventors: KHANNA, May
KHANNA, Rajesh
GOKHALE, Vijay
CHAWLA, Reena
Title: CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF
Abstract:
The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.