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1. (WO2017062762) METHODS, MEDICAL DEVICES AND KITS FOR MODIFYING THE LUMINAL PROFILE OF A BODY VESSEL
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What is claimed is:

1. A method of modifying the luminal profile of a body vessel of an animal, comprising:

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

2. The method of claim 1 , wherein said body vessel comprises a vein.

3. The method of claim 1 , wherein the contrast dye contains a crosslinking agent.

4. The method of claim 1 , wherein the bulking agent contains a crosslinking agent.

5. The method of claim 1 , further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site.

6. The method of claim 5, wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed before the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

7. The method of claim 5, wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed simultaneously with the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

8. The method of claim 5, wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed after the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

9. The method of claim 5, further comprising passing a buffer through the cannula between the bulking agent and the crosslinking agent.

10. A method of modifying the luminal profile of a body vessel of an animal, comprising:

locating a position of a natural valve within said body vessel;

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel and adjacent the natural valve;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

1 1. The method of claim 10, wherein said body vessel comprises a vein.

12. The method of claim 10, wherein the contrast dye contains a crosslinking agent.

13. The method of claim 10, wherein the bulking agent contains a crosslinking agent.

14. The method of claim 10, further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site.

15. The method of claim 1 , wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed before the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

16. The method of claim 14, wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed simultaneously with the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

17. The method of claim 14, wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed after the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

18. The method of claim 14, further comprising passing a buffer through the cannula

between the bulking agent and the crosslinking agent.

19. A method of modifying the luminal profile of a body vessel of an animal, comprising:

locating a position of a natural valve within said body vessel;

measuring the inner diameter of said body vessel at the position of the natural valve;

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel and adjacent the natural valve;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site;

passing bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site; and

measuring the inner diameter of the body vessel at the position of the natural valve.

20. The method of claim 19, wherein said body vessel comprises a vein.