US2016055594 RATIONAL COMBINATION THERAPY FOR THE TREATMENT OF CANCER

1. (WO2017062520) RATIONAL COMBINATION THERAPY FOR THE TREATMENT OF CANCER

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Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2017/062520		International Application No.:		PCT/US2016/055594
Publication Date:		13.04.2017		International Filing Date:		05.10.2016

IPC:

A61K 45/06 (2006.01), A61K 31/337 (2006.01), A61K 31/52 (2006.01), A61K 31/704 (2006.01), A61P 35/00 (2006.01)

Applicants:

MEMORIAL SLOAN KETTERING CANCER CENTER [US/US]; 1275 York Avenue New York, New York 10065 (US)

Inventors:

CHIOSIS, Gabriela; (US).
TALDONE, Tony; (US).
SHRESTHA, Liza; (US).
KOREN, John; (US).
GOMES-DAGAMA, Erica M.; (US).
RODINA, Anna; (US)

Agent:

REARICK, John P.; (US).
AUGST, Alexander D.; (US).
BUTEAU, Kristen C.; (US).
CAHILL, John J.; (US).
HAULBROOK, William R.; (US).
LUCA, Cassandra G.; (US).
JARRELL, Brenda Herschbach; (US).
LI, Xiaodong; (US).
LYON, Charles E.; (US).
MEDINA, Rolando; (US).
MONROE, Margo R.; (US).
NGUYEN, Suzanne P.; (US).
NIHAN, Danielle M.; (US).
PACE, Nicholas J.; (US).
PELLIGRINO, Jeffrey S.; (US).
PYSHER, Paul A.; (US).
REESE, Brian E.; (US).
ROHLFS, Elizabeth M.; (US).
SAHR, Robert N.; (US).
SCHONEWALD, Stephanie L.; (US).
SHAIKH, Nishat A.; (US).
SHINALL, Michael A.; (US).
SMITH, Maria C.; (US).
SUH, Su Kyung; (US).
VETTER, Michael L.; (US).
VRABLIK, Tracy L.; (US).
WANG, Gang; (US)

Priority Data:

62/237,470

05.10.2015

Title

(EN) RATIONAL COMBINATION THERAPY FOR THE TREATMENT OF CANCER
(FR) POLYTHÉRAPIE RATIONELLE POUR LE TRAITEMENT DU CANCER

Abstract:

(EN)The disclosure provides methods of using inhibitors of chaperone proteins, such as HSP90 inhibitors, in combination with agents that increase proteotoxic stress on tumor cells or agents that induce a biochemical rewiring of the chaperome. The proteotoxic agents are administered prior to administration of the chaperone proteins to achieve synergistic activity.
(FR)La présente invention concerne des procédés d'utilisation d'inhibiteurs de protéines chaperon, tels que des inhibiteurs de HSP90, en association avec des agents qui augmentent le stress protéotoxique sur des cellules tumorales ou des agents qui induisent un recâblage biochimique du chaperon. Les agents protéotoxiques sont administrés préalablement à l'administration des protéines chaperon pour obtenir une synergie d'activité.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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